It's Monday, April 28 and the Tigers (18-10) are in Houston to take on the Astros (14-13). Jack Flaherty is slated to take the mound for Detroit against Ronel Blanco for Houston. Houston is coming off a 7-3 win over Kansas City that broke a two-game losing streak that featured zero runs scored.

Preview the April 28 matchup between the Houston Astros and Detroit Tigers with odds over/under, game spread, betting lines and more.

First meeting; Astros won regular-season series 4-2 in 2024; Tigers won 2-0 in AL Wild Card Series The Tigers roll into the Space City with a little momentum after sweeping the Baltimore Orioles over the weekend in 3 games.

The Houston Astros will have the bottom of the rotation rolling as probables are set for the series against the red hot Detroit Tigers.

Pregame analysis and predictions of the Detroit Tigers vs. Houston Astros MLB game to be played on April 28, 2025 on ESPN.