This paper describes Unbend - a new method for measuring and correcting motions in cryo-EM images, with a particular emphasis on more challenging in situ samples such as lamella and whole cells. The ...

Breakthrough cryo-EM structures expose multiple drug targets in an essential HSV-1 replication protein.An international ...

Frogs have made significant contributions to Fred Hutch science over the years as a model organism that shares much of our ...

This study determined cryo-EM structures of midnolin-proteasome complexes, providing mechanistic insights to ...

An international research team has successfully identified the initial high-resolution structures of the herpes simplex virus ...

The RAD52-DNA complex is a dynamic guardian of genomic stability. When this balance falters, cells may either self-destruct or, worse, turn cancerous.

Researchers used cryo-EM to study how the HIV enzyme integrase arranges in 3D to slip its DNA into the host genome and pack ...

The ability to sense heat protects the body from burns and injury. But how the body actually feels temperature has remained ...

New research reveals how tiny electrical gates in the brain, known as NMDA receptors, control learning, memory, and neuron ...

A Jacobs School researcher is focused on learning more about how tight junctions form naturally — and how their breakdown can lead to disease.

Current treatments for herpes simplex virus 1 (HSV-1) mainly target the viral DNA polymerase, but resistance is becoming an increasing problem. By understanding how HSV-1 initiates replication, ...

Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome—comprising about 17% of the genome. It is commonly called a "jumping gene" or ...