In drug discovery, various methods of lead generation exist that give researchers a starting point to develop drugs further and make them as efficacious as possible. High-throughput screening is a ...

A chemogenomic library is a collection of well-defined pharmacological agents. A hit from such a set in a phenotypic screen suggests that the annotated target or targets of the probe molecules are ...

The size of compound libraries amenable to standard virtual ligand screening (VLS) approaches is limited by the time and cost involved in screening. To keep pace with the increasing size of virtual ...

Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organization (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the ...

With a collection of more than 1.6 million items, the Library of Congress is the world's largest repository of moving images. But beyond storing and cataloging precious films from the earliest days of ...

The identification of compounds that could be promising candidates for drug development has become easier following new research. Scientists have developed a series of "filters" that can be used to ...

We have developed an approach for screening ordered arrays of yeast artificial-chromosome (YAC) clones containing human DNA that is based on the polymerase chain reaction (PCR). This approach is ...