Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 12 (Jun. 5, 2001), pp. 6935-6940 (6 pages) To investigate the molecular basis of the voltage sensor that ...

George Rodney Lab Research Focus Real-time imaging of sub-cellular reactive oxygen species, Ca2+ signaling, and excitation-contraction coupling in skeletal muscle under physiological and ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

Heart muscle excitation-contraction (E-C) coupling is governed by Ca²⁺ release units (CRUs) whereby Ca²⁺ influx via L-type Ca²⁺ channels (Cav1.2) triggers Ca²⁺ release from juxtaposed Ca²⁺ release ...

It is important to understand the principles of normal neuromuscular transmission when using neuromuscular blocking agents. The neuromuscular junction consists of the motor-nerve terminus, the ...