Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech.

louisville running back isaac brown (1) runs downfield against virginia tech during the first half of an ncaa college football game, saturday, nov. 1, 2025, in blacksburg, va. (ap photo/robert simmons) The Louisville Cardinals won against the Virginia Tech Hokies in Week 10 of the 2025 college football season.

Metallica's iconic “Enter Sandman" has been a game-day anthem in Blacksburg for over a quarter-century. “Having the courage to embrace something like that is very important,” said Columbia University lecturer Joe Favorito,