Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. In degenerated NP tissue, MRTF-A was activated by increased matrix stiffness and ...

A new study, led by Prof. Liu from the department of pharmacy, University of Electronic Science and Technology of China, discovered that the extracellular cell matrix (ECM) could induce the drug ...

Cardiovascular disease is the leading cause of death in humans. Worldwide, as the population ages, the burden of treating heart failure is increasing; opportunities for heart transplantation cannot ...

(Nanowerk News) Imagine a world inside your body where tiny cells are like workers building and repairing tissue structures. They interact with their surroundings, which include a scaffold called the ...

A preconditioning method for the finite element stiffness matrix is given in this paper. The triangulation is refined in a subregion; the preconditioning process is composed of resolution of two ...

Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly nonlinear mechanical properties. While the linear elasticity of the matrix can significantly impact cell ...

Researchers in the United States and Japan have discovered a new mechanism that links age-related cartilage tissue stiffening with the repression of a key protein associated with longevity, and the ...

For in vitro cellular assays, the extracellular matrix—the material between cells—often is overlooked, but changes within this microenvironment affect cells’ proliferation and differentiation and, ...