New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

New study shows that targeting an oft-drugged family of cell membrane receptors with biased modulators can expand potential ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane ...

Septerna's Native Complex platform isolates GPCRs in their native form, enabling advanced drug discovery for previously undruggable targets, including oral small-molecule therapeutics. Lead molecule ...

GPCRs are the largest receptor class, affecting almost every aspect of human physiology, with 35% of all approved drugs acting on GPCRs. They regulate sensory and neuronal signaling, as well as a ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G ...

Having backed Superluminal Medicines’ series A last year, Eli Lilly has now signed a $1.3 billion pact with the G protein-coupled receptor biotech. The deal will see Superluminal use its GPCR platform ...

G protein-coupled receptors (GPCRs) for hormones and neurotransmitters evolved to be the most important means of communication between cells and tissues in higher organisms. They are responsive to a ...