Methanotrophic bacteria consume 30 million metric tons of methane per year and have captivated researchers for their natural ability to convert the potent greenhouse gas into usable fuel. Yet we know ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 52 (December 30, 2014), pp. 18454-18459 (6 pages) Enzymes use protein architectures to create highly ...

Chemists use activity-based protein profiling (ABPP) to look for functional enzymes with specific activities, sometimes in hopes of finding leads for drug development. They search for these enzymes ...

Bacteria constantly evolve new ways to evade antibacterial drugs. One emerging resistance mechanism involves an enzyme called New Delhi metallo-β-lactamase-1 (NDM-1). NDM-1 can hydrolyze most ...

Natural products derived from microorganisms are a promising source of new active ingredients, but are often produced only in ...