The cytochrome P450 (CYP) enzymes are a protein superfamily involved in the synthesis and metabolism of drugs, toxins and normal cellular components. The CYP family of enzymes have been identified in ...

Brain cytochrome P450 (CYP) enzymes represent a specialised set of metabolic proteins that, while less abundant than their hepatic counterparts, play an increasingly acknowledged role in the local ...

The first-ever structure of a full-length P450 enzyme has been solved. Cells use these enzymes to synthesize hormones and metabolize drugs. Chemists would like to engineer them to carry out reactions ...

A family of nearly 3,000 artificial cytochrome P450 enzymes has been created by a California Institute of Technology team's efforts to recombine sections of three natural cytochrome P450s, a large ...

René Höfer, Benoît Boachon, Hugues Renault, Carole Gavira, Laurence Miesch, Juliana Iglesias, Jean-François Ginglinger, Lionel Allouche, Michel Miesch, Sebastien Grec, Romain Larbat and Danièle ...

Opioids have long been the mainstay of pain control for patients with cancer; however, their use in patients with chronic, moderate to severe pain has increased greatly in the past decade. The risk of ...

The drug target of AIs is the enzyme aromatase, which belongs to the superfamily of CYP450 enzymes. Aromatase converts androgens (testosterone, androstenedione) to estrogens and its inhibition results ...

Cytochrome P450 enzymes of the CYP720B subfamily play a central role in the biosynthesis of diterpene resin acids (DRAs), which are a major component of the conifer oleoresin defense system. CYP720Bs ...

The superfamily of proteins called cytochrome P450 (CYP) enzymes are involved in the synthesis and metabolism of a range of internal and external cellular components. These enzymes have been ...

The current evidence highlights CYP2D6 to be the most relevant molecular diagnostic factor to be utilized for stratified use of tamoxifen in the endocrine treatment setting of postmenopausal breast ...