DUBAI—Iran has been urgently signaling that it seeks an end to hostilities and resumption of talks over its nuclear programs, sending messages to Israel and the U.S. via Arab intermediaries, Middle Eastern and European officials said.

Smoke and missiles have lit up the skies in Israel and Iran in a fierce standoff triggered by fears over Tehran’s expanding nuclear program. Since June 13, hundreds of military strikes have been exchanged as the two nations remain locked in a conflict that shows no signs of abating.

Israel’s campaign, militarily and rhetorically, has quickly evolved beyond its initial targets. Over the weekend, it hit Iran’s energy facilities, including a gas depot and an oil refinery, triggering huge fires and spewing smoke across the sprawling capital of about ten million people.